FMD多施設共同研究（FMD-J研究）

研究の概要

FMD-J 研究は、動脈硬化性心血管疾患診療指標としての血流介在上腕動脈血管拡張反応（Flow-mediated vasodilatation：FMD）検査の有用性の確立を研究課題とした多施設共同の臨床研究であり、以下の 3 つの研究より構成されています。
【研究 A】FMD の冠動脈疾患症例における予後予測指標としての有用性を検証する。
【研究 B】FMD の高血圧・糖尿病症例における潜在性臓器障害進展予測指標としての有用性を検証する。
【研究 C】一般健診者を対象に FMD の経年変化を評価する。　
本研究は、公益信託日本動脈硬化予防研究基金（JAPF）の助成にて実施されました。
研究データ収集は2016年12月で終了していますが、データ解析は2030年3月まで継続します。この度、日本血管不全学会の協力を得て、ＦＭＤ－Ｊ研究の情報を日本血管不全学会サイト内に掲載し、ＦＭＤを中心とした血管機能検査の測定方法マニュアルをダウンロードできるようにしました。また、今後、ＦＭＤ－Ｊ研究に関連するお知らせがございましたら、当ページにてご案内いたします。

これまでの成果

Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study.
Oda N, Kajikawa M, Maruhashi T, Kishimoto S, Yusoff FM, Goto C, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y.PLoS One. 2020 Dec 3;15(12):e0243216. doi: 10.1371/journal.pone.0243216. eCollection 2020.PMID: 33270724

Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension.
Tomiyama H, Vlachopoulos C, Xaplanteris P, Nakano H, Shiina K, Ishizu T, Kohro T, Higashi Y, Takase B, Suzuki T, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Tanaka A, Maemura K, Ohya Y, Furukawa T, Ito H, Ohkuma T, Ninomiya T, Chikamori T, Yamashina A, Ueda SI.Hypertens Res. 2020 Nov;43(11):1284-1292. doi: 10.1038/s41440-020-0472-7. Epub 2020 May 26.PMID: 32457429

Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Han Y, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.Hypertens Res. 2020 Aug;43(8):781-790. doi: 10.1038/s41440-020-0420-6. Epub 2020 Mar 9.PMID: 32152482

Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery.
Maruhashi T, Kajikawa M, Kishimoto S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Han Y, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.J Am Heart Assoc. 2020 Jan 21;9(2):e013915. doi: 10.1161/JAHA.119.013915. Epub 2020 Jan 8.PMID: 31910779

Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index β-Transformed Value as Risk Marker for Cardiovascular Disease.
Tomiyama H, Ohkuma T, Ninomiya T, Nakano H, Matsumoto C, Avolio A, Kohro T, Higashi Y, Maruhashi T, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Chikamori T, Yamashina A.J Am Heart Assoc. 2019 Dec 17;8(24):e013004. doi: 10.1161/JAHA.119.013004. Epub 2019 Dec 11.PMID: 31822217

Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease　- Post Hoc Analysis of the FMD-J Study A.
Kajikawa M, Maruhashi T, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.Circ J. 2019 Apr 25;83(5):1064-1071. doi: 10.1253/circj.CJ-18-1082. Epub 2019 Mar 26.PMID: 30918221

Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.J Am Heart Assoc. 2018 Jul 12;7(14):e008588. doi: 10.1161/JAHA.118.008588.PMID: 30005558

Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension.
Tanaka A, Kawaguchi A, Tomiyama H, Ishizu T, Matsumoto C, Higashi Y, Takase B, Suzuki T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A, Node K.Int J Cardiol. 2018 Dec 1;272:308-313. doi: 10.1016/j.ijcard.2018.06.017. Epub 2018 Jun 6.PMID: 29895425

Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.Atherosclerosis. 2018 Jan;268:92-98. doi: 10.1016/j.atherosclerosis.2017.11.022. Epub 2017 Nov 22.PMID: 29195110

Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension.
Tomiyama H, Ishizu T, Kohro T, Matsumoto C, Higashi Y, Takase B, Suzuki T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.Int J Cardiol. 2018 Feb 15;253:161-166. doi: 10.1016/j.ijcard.2017.11.022. Epub 2017 Nov 12.PMID: 29174285

Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan).
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FBM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.Hypertension. 2017 Oct;70(4):790-797. doi: 10.1161/HYPERTENSIONAHA.117.09612. Epub 2017 Aug 14.PMID: 28808069

Association Between Waist-to-Height Ratio and Endothelial Dysfunction in Patients With Morbidity　- A Report From the FMD-J Study.
Tokushige A, Ueda S, Tomiyama H, Ohishi M, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.Circ J. 2017 Nov 24;81(12):1911-1918. doi: 10.1253/circj.CJ-17-0211. Epub 2017 Jul 7.PMID: 28690284

Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study.
Oda N, Kajikawa M, Maruhashi T, Iwamoto Y, Kishimoto S, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.Int J Cardiol. 2017 Mar 1;230:523-528. doi: 10.1016/j.ijcard.2016.12.065. Epub 2016 Dec 21.PMID: 28057366

Relationship between serum triglyceride levels and endothelial function in a large community-based study.
Kajikawa M, Maruhashi T, Matsumoto T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Aibara Y, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y.Atherosclerosis. 2016 Jun;249:70-5. doi: 10.1016/j.atherosclerosis.2016.03.035. Epub 2016 Apr 1.PMID: 27065244

Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese.
Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A.Atherosclerosis. 2015 Oct;242(2):433-42. doi: 10.1016/j.atherosclerosis.2015.08.001. Epub 2015 Aug 5.PMID: 26291496

Autonomic nervous activation triggered during induction of reactive hyperemia exerts a greater influence on the measured reactive hyperemia index by peripheral arterial tonometry than on flow-mediated vasodilatation of the brachial artery in patients with hypertension.
Tomiyama H, Yoshida M, Higashi Y, Takase B, Furumoto T, Kario K, Ohya Y, Yamashina A; sub-group study of FMD-J.Hypertens Res. 2014 Oct;37(10):914-8. doi: 10.1038/hr.2014.103. Epub 2014 Jun 19.PMID: 24942768

Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women.
Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.BMJ Open. 2013 Nov 8;3(11):e003659. doi: 10.1136/bmjopen-2013-003659.PMID: 24213096

Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y.Heart. 2013 Dec;99(24):1837-42. doi: 10.1136/heartjnl-2013-304739. Epub 2013 Oct 23.PMID: 24153417

A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery.
Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.Int Heart J. 2012;53(3):170-5. doi: 10.1536/ihj.53.170.PMID: 22790685

Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y.Circulation. 2012 Jul 31;126(5):598-603. doi: 10.1161/CIRCULATIONAHA.112.105775. Epub 2012 Jul 6.PMID: 22773454